A 0h/1h protocol for safe early discharge of chest pain patients

A 0h/1h protocol for safe early discharge of chest pain patients

Objectives Guidelines recommend a 0-hour/1-hour high-sensitivity cardiac troponin T (hs-cTnT) diagnostic strategy in acute chest pain patients. There are, however, little data on the performance of this strategy when combined with clinical risk stratification. We aimed to evaluate the diagnostic accuracy of an accelerated diagnostic protocol (ADP) using the 0-hour/1-hour hs-cTnT strategy together with an…

Effects of oxygen therapy on wall motion score index in patients with ST Elevation Myocardial Infarction – The randomized SOCCER trial

Effects of oxygen therapy on wall motion score index in patients with ST Elevation Myocardial Infarction – The randomized SOCCER trial

Background Although oxygen (O2 ) is routinely used in patients with acute myocardial infarction (AMI), it may have negative effects. In this substudy of the SOCCER trial, we aimed to evaluate the effects of O2 -treatment on myocardial function in patients with ST elevation myocardial infarction (STEMI). Methods Normoxic (≥94%) STEMI patients were randomized in…

A simplified left ventricular end-diastolic mean wall thickness-to-volume ratio estimated from left ventricular mass and end-diastolic volume distinguishes physiological from pathological hypertrophy
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A simplified left ventricular end-diastolic mean wall thickness-to-volume ratio estimated from left ventricular mass and end-diastolic volume distinguishes physiological from pathological hypertrophy

Left ventricular end-diastolic mean wall thickness (LVEDMWT) can be simply estimated from left ventricular mass and left ventricular end-diastolic volume with high accuracy and precision. Estimated LVEDMWT can in turn be used to calculate thickness-to-volume ratio (TVR) as a new index of relative wall thickness. The maximum TVR found in endurance athletes was lower than…

Effect of oxygen therapy on myocardial salvage in ST elevation myocardial infarction: The randomized SOCCER trial

Effect of oxygen therapy on myocardial salvage in ST elevation myocardial infarction: The randomized SOCCER trial

Objective Recent studies suggest that administration of O2 in patients with acute myocardial infarction may have negative effects. With the use of cardiac MRI (CMR), we evaluated the effects of supplemental O2 in patients with ST elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary intervention (PCI). Materials and methods This study was a randomized-controlled…

Diagnostic Accuracy of High-Sensitivity Cardiac Troponin T at Presentation Combined With History and ECG for Ruling Out Major Adverse Cardiac Events

Diagnostic Accuracy of High-Sensitivity Cardiac Troponin T at Presentation Combined With History and ECG for Ruling Out Major Adverse Cardiac Events

Study objective We evaluate the diagnostic accuracy of a high-sensitivity cardiac troponin T (hs-cTnT) level less than 5 ng/L or less than or equal to 14 ng/L at emergency department (ED) presentation, combined with the emergency physician’s assessment of history and ECG, for ruling out major adverse cardiac events within 30 days. Methods This prospective…

A 1-h Combination Algorithm Allows Fast Rule-Out and Rule-In of Major Adverse Cardiac Events

A 1-h Combination Algorithm Allows Fast Rule-Out and Rule-In of Major Adverse Cardiac Events

Background A 1-h algorithm based on high-sensitivity cardiac troponin T (hs-cTnT) testing at presentation and again 1 h thereafter has been shown to accurately rule out acute myocardial infarction. Objectives The goal of the study was to evaluate the diagnostic accuracy of the 1-h algorithm when supplemented with patient history and an electrocardiogram (ECG) (the…

The SOCCER-study: Effects of Oxygen Therapy on Myocardial Salvage in ST Elevation Myocardial Infarction – A Randomized Trial
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The SOCCER-study: Effects of Oxygen Therapy on Myocardial Salvage in ST Elevation Myocardial Infarction – A Randomized Trial

Our results showing no difference in MSI between the O2 and air groups suggests that supplemental O2 did not affect the efficacy of reperfusion in STEMI patients accepted for acute PCI. These results support the safety of withholding supplemental oxygen in normoxic STEMI patients.